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It is likely that hGH and sex steroids are necessary to achieve an optimal growth spurt; however, patients achieve greater height with sex steroids alone than with exclusive administration or production of hGH. No, it won't cause kids to grow hair on their hands, become infertile, go blind, or develop new emotional problems. In a related manner, other authors have suggested that an alteration in hGH secretion per se sets off the PCOS cascade. The mechanism of GnRH pulsatility and control is unknown but has been postulated to involve catecholamines and glutamate along with dopaminergic, noradrenergic, and opioid neurons and their interaction with the hypothalamus.

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