AVONEX PACKAGE INSERT PDF

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1. Package leaflet: Information for the user. AVONEX 30 micrograms/ ml solution for Injection. (Interferon beta-1a). Pre-filled syringe. Read all of this leaflet. Package leaflet: Information for the user. AVONEX 30 micrograms/ml solution for injection in pre-filled pen. (Interferon beta-1a). Pre-filled pen. Read all of this. Formal hepatic drug metabolism studies with AVONEX PS/AVONEX PEN in This leaflet is part III of a three-part “Product Monograph”.

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Major Natalizumab should be used with caution with interferon beta because of the potential for increased risk of progressive multifocal leukoencephalopathy PML and other serious infections with combined use. The indicated dose is based on data suggesting that early initiation of interferon beta-1a therapy delays the onset of clinically definite MS in high-risk patients who have recently experienced a demyelinating event but do not avonx have clinical MS.

NNRTIs may cause liver damage in the context of hypersensitivity reactions or by direct toxic effects. The buttock is not a suitable site for injection. Inject subcutaneously using inssrt dart-like motion into the outer surface of the upper arm, abdomen, thigh, or buttock. Interferon beta-1a is administered by intramuscular IM or subcutaneous SC injection depending upon the product. Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate: The Rebif liquid is clear to slightly yellow.

No adequate or well-controlled pregnancy studies have been done. Nevirapine may cause liver damage in the context of hypersensitivity reactions or by direct toxic effects. Biogen NZ Biopharma Limited. Doravirine; Lamivudine; Tenofovir disoproxil fumarate: Allergic reactions, including anaphylaxis have been reported with interferon beta-1a use.

Your doctor can discuss with you the possible risks involved. Take care not to inject intradermally. It is not known whether these events were related to the effects of multiple sclerosis alone, interferon beta-1a therapy, or a combination of both. Administration of Avonex pre-filled syringe using the Avostartgrip titration kit: If your doctor tells you to stop using AVONEX or the expiry date has passed, ask your pharmacist what to do with any medicine that is left over.

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Used to treat epilepsy prevent fits. Furthermore, they state that there are lower rates of liver-related mortality in coinfected patients taking HAART, even in those with end-stage liver disease, compared with patients not paciage HAART.

The most common side effect is to feel ‘flu-like’ symptoms, e. Monitoring of blood cell counts is recommended at regular intervals 1, 3, and 6 months following initiation of interferon beta-1a therapy and then periodically thereafter in absence of clinical symptoms. Interferon beta is metabolized in the liver. Patients should be closely monitored for signs of hepatic injury and caution exercised when interferon beta-1a is concomitantly with other drugs associated with hepatic injury e.

Interferons and anti-retroviral nucleoside reverse transcriptase inhibitors NRTIs can both cause hepatotoxicity. Things you must do: Reconstitution and Administration of Avonex lyophilized powder: Remove 1 Administration Dose Pack from refrigerator about 30 minutes prior to use to warm to room temperature.

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Reduce the risk of relapse. Use with caution in patients with hepatic disease. Treatment with interferon beta-1a should be immediately stopped if jaundice or other clinical signs of liver dysfunction appear; the potential for rapid progression to liver failure exists if inset drug is continued. Discontinuation of interferon therapy is recommended.

These side effects generally occur less often as therapy continues. Hold syringe upright so that the rubber cap faces up.

The effects of interferon beta-1a during labor and delivery are unknown. Reduced sensitivity to touch. Paxkage upon breast milk samples obtained during the study, the authors estimated that the maximum weight-adjusted dosage that an infant would receive was 0.

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Avonex is administered as an IM injection. Any of the other ingredients listed at the end of this leaflet. Shaking can damage this medicine. Use only for the person for whom it has been prescribed. Increased sweating or flushing. The result is a progressive neurologic dysfunction.

There is some evidence that interferon beta has greater in vitro antiproliferative effects against many solid tumor cell lines than interferon alpha.

Interferons and efavirenz can both cause hepatotoxicity. Patients may self-inject only if their physician determines that it is appropriate, and with medical follow-up, and after proper training in intramuscular injection technique. Subcutaneous administration of interferon beta-1a should not be substituted for intramuscular administration. Your doctor may do blood tests before you start treatment and from time to time to monitor your progress and prevent unwanted side effects.

Pull the protective cover straight off the needle; do not twist the cover off. Push down on blue activation button with thumb and count to The biologic responses of interferon beta therapy may be evaluated via the following markers: Major Patients receiving lamivudine with interferons with or without ribavirin should be closely monitored for treatment-associated toxicities, especially hepatic decompensation.

Interferon beta-1a acts similarly to native interferon beta. Interferon beta-1a should be used with caution in patients with depression.

They may differ from the information contained in this leaflet. Be careful not to push the plunger while attaching the needle. You may need urgent medical attention or hospitalisation.

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