Intoxicación por cafeína en un recien nacido prematuro Caffeine citrate is used as first-line therapy in neonates to treat or prevent apnea of prematurity. This is not the most recent version of this Review. Please comment on the current version. view the current version 20 Jan Si su bebé no tenía apnea ni bradicardia en UCIN o si la frecuencia o puede recibir medicamentos (teofilina o cafeína) para disminuir los episodios. Los bebés recién nacidos prematuros corren el riesgo de hernias, que.
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Preterm infants with birth weight of to 1, g treated with caffeine during the first 10 days have a reduced rate of bronchopulmonary dysplasia, and present a better neurodevelopmental outcome at 18 to 21 months than a control group.
This study showed that neonates with detectable and undetectable levels of caffeine in umbilical cord blood had similar occurrence of apnea, and among the neonates who presented apnea, occurrence was later in preterm neonates with detectable levels of caffeine.
Efficacy of caffeine in treatment of apnea in the low-birth-weight infant. Echocardiogram was performed in all preterm neonates with clinical suspicion of PDA.
cafeina en apnea del prematuro pdf – PDF Files
Serum levels of caffeine in umbilical cord and apnea of prematurity. Effects of maternal smoking and caffeine habits on infantile apnea: Long-term effects of caffeine therapy for apnea of prematurity. A simple liquid chromatographic method applied to determine caffeine in plasma and tissues.
ABC of antenatal care. To determine the influence of presence of caffeine in umbilical cord blood on apnea occurrence. Eighty-seven newborns with and 40 without detectable caffeine in umbilical cord blood were studied. N Engl J Med. This study aimed at determining the influence of presence of caffeine in umbilical cord blood on the incidence and time of occurrence of apnea of prematurity in the first days of life. For the diagnosis of meningitis, those with abnormal cerebrospinal fluid and positive culture were considered.
One limitation of this study is the lack of comparison in the number of apnea spells between both groups. La apnea del sueno en el bebe prematuro. According to the service routine, preterm neonates whose birth weight was above 1, g and presented any clinical problem including apnea were submitted to CUS.
Results Umbilical blood was collected in preterm neonates; 21 of them were subsequently excluded seven for presenting apnea once with no need for treatment, five for remaining in mechanical ventilation until the fourth day of life, three for PIVH degrees 3 and 4, one for exchange transfusion, five for methylxantine prior to extubationand three were lost two due to insufficient sampled quantity for caffeine dosage and one due to family request.
A prospective cohort study with preterm newborns with birth weight lower than 2, g was undertaken. Discussion This study showed that neonates with detectable and undetectable levels of caffeine in umbilical cord blood had similar occurrence of apnea, and among the neonates who presented apnea, occurrence was later in preterm neonates with detectable levels of caffeine.
All patients with diagnosis of sepsis were submitted to lumbar puncture. Display posts from previous: The logistic regression model employed for the whole studied population took the presence of caffeine in umbilical cord blood as a dependent factor, and gestational age, occurrence of apnea, use of CPAP and mechanical ventilation as independent factors.
Acknowledgements We thank Vania Naomi Hirakata for her assistance with the statistical analysis, and Carmen Pilla, BSc, for her assistance with the caffeine laboratory analysis. Table 1 shows the group characteristics.
A rapid Cadeina method for monitoring plasma levels of caffeine and theophylline using solid phase extraction columns. Admin Administrateur Offline Joined: The first choice for treatment of apnea of prematurity in our unit is methylxantine, and its use would bias the result.
Logistic regression analysis showed that none of those variables was associated with presence of caffeine in umbilical cord blood.
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Tratamientos para evitar la apnea. Group characteristics were analyzed using chi-square test, Fisher’s exact test, except for the birth weight variable Student’s t test and Apgar score Mann-Whitney spnea.
The simultaneous determination of theophylline, theobromine and caffeine in plasma by high performance liquid chromatography. Newborns were followed for the first 4 days for occurrence of apnea spells. Evaluation of interleukin-6, tumour necrosis factor-alpha and interleukin-1beta for early diagnosis of neonatal sepsis.
En la apnea, la respiracion cesa temporalmente y luego regresa a la normalidad. The method used in the gestational age assessment was preferably the obstetric gestational age obtained through ultrasonography in the first weeks of fetal life or, if such data were unavailable, the date of most recent menstruation preamturo through clinical exam of the neonate.
apnew A United States national reference for fetal growth. Group 1 was formed by 87 newborns and group 2 by Prematurity, apnea, caffeine, low-birth-weight infant. Pediatr Clin North Am. As caffeine is a substance that crosses the placental barrier, it could have an intrauterine stimulation of the fetus’s respiratory center.
Simultaneous high-performance liquid chromatographic determination of caffeine and theophylline for routine drug monitoring in human plasma.