Carcinomas of the Ampulla of Vater are rare tumors, accounting for % of A review of chemotherapy options available for ampullary cancer. Metastasis of breast cancer to major duodenal papilla Palabras clave: Ampolla de Vater; Neoplasias de la mama; Ictericia (fuente: DeCS BIREME). Periampullary tumors are neoplasms that arise in the vicinity of the ampulla of Vater. Neoplasms that arise in this site can originate from the.

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Pancreaticoduodenectomy Wipple procedure is regarded as canceer standard treatment for ampullary cancers whereas endoscopic ampullectomy is typically reserved for benign ampullary lesions. The efficacy of frontline platinum-based combination chemotherapy in advanced adenocarcinoma of the ampulla of Vater. Demographics, histological features, stage, treatment received and outcome of 20 cases of ampullary carcinoma.

Jpn J Cancer Res. To date, there are no consistent data concerning biliary tree tumors and antiangiogenic drugs and only a few studies concerning anti-epidermal growth factor receptor EGFR drugs.

Histological examination showed a carcinoma, with infiltration in the duodenal mucosa.

Median survival was 22 mo range: Tumor staging with laparoscopy and laparoscopic ultrasonography. According to the Kimura classification[ cabcer ], ampullary cancers were divided in intestinal and pancreatobiliary, depending on their histological differentiation. Most ampullary tumors are adenocarcinomas, but are occasionally papillary, adenosquamous or mucinous.

In agreement with these data, adjuvant gemcitabine-based chemotherapy was found to be a significant independent predictor of a favourable prognosis in patients with hilar cholangiocarcinoma[ 51 ]. Tumor of the ampulla of Vater: Time to progression; LD: Immunohistochemical staining in the diagnosis of pancreatobiliary and ampulla of Vater adenocarcinoma: Experience with consecutive tumors of the duodenum, ampulla, head of the pancreas, and distal common bile duct.


Adenocarcinoma of the ampulla of Vater. In this report we present a case of biliary obstruction due to metastatic breast cancer to the major duodenal papilla. Recurrence rate is high in this population; therefore, surveillance endoscopy is indicated.

The concept of ampullary carcinoma as a distinct entity is challenged by the categorization of dd into intestinal type and biliopancreatic type histologically.

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Tumors of ampulla of Vater: A case series and review of chemotherapy options

Utility of immunohistochemistry in distinguishing primary adenocarcinomas from metastatic breast carcinomas in the gastrointestinal tract. Metastasis of breast cancer to major duodenal papilla.

One phase III multicenter randomized trial tested the role of adjuvant chemotherapy in pancreatico-biliary carcinoma[ 46 ]. Time to progression; LD: Adjuvant vaterr with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: Adjuvant chemoradiation versus surgery alone for adenocarcinoma of the ampulla of Vater.


Metastasis is an infrequent cause of tumor involvement of vqter major duodenal papilla and of cholestasis. The patient underwent a modified mastectomy and adjuvant chemotherapy for bone metastases to the lumbar spine in December The chemotherapic options available for ampullary cancer are also reviewed.

Bhatia et al[ 38 ] Due to the invasive nature of the lesion, palliative treatment was offered with replacement of the plastic stent for a metallic one the patient had significant improvement of the cholestatic syndrome and abdominal pain. Targeted therapies represent a new, interesting chapter in cancer treatment.

Factors predictive of survival in ampullary carcinoma. Long-term survival and recurrence patterns in ampullary cancer. The median age at diagnosis was 64 years range: Survival after resection of ampullary carcinoma: Table 1 Demographics, histological features, stage, treatment received and outcome of 20 cases of ampullary carcinoma.


The primary role of the adjuvant vatet in the treatment of pancreatic cancer firstly emerged in the ESPAC study[ 47 ], and more recently confirmed by the CONKO study[ 4849 ]. Transpapillary IDUS demonstrats good accuracy in the detection of tumor infiltration of ampullary cancer[ 30 ], whereas CT and MRI are recommended for the detection of distant metastases.

Cetuximab, gemcitabine, and oxaliplatin in patients with unresectable advanced or metastatic biliary tract cancer: No residual tumor was found in pancreaticoduodenectomy specimens of these 4 patients.

Surgery represents the main therapeutic approach for ampullary cancer, whilst unresectable tumors can be treated with either radiotherapy or chemotherapy. Histopathology, molecular features and clinical outcome clearly identify two distinct types of ampullary cancer, and their differences should be taken into account both in selecting medical treatments and in planning clinical trials.


Ampolla de Vater; Neoplasias de la mama; Ictericia fuente: Toh et al reported 25 patients 13 men, 12 women with a median age of 65 years who had an ampullary tumor. The ampulla is 1. Similar distribution of demographic characteristics and stage between ampullary and other biliary tract cancers was observed.

This figure demonstrates the process of kocherization of the duodenum. Carcinoma of the ampulla of Vater. September 30, admin. Presentation of diagnosis and therapy by endoscopic interventional and surgical methods].

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