Citicoline is a medicine available in a number of countries worldwide. A list of US medications equivalent to Citicoline is available on the website. Choline C 11 Injection, for intravenous use. Initial U.S. Approval: INDICATIONS AND USAGE Choline C The Federal Food, Drug, and Cosmetic Act requires that manufacturers and distributors who wish to market dietary supplements that contain.

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Muscarinic acetylcholine receptor modulators. Journal of Neuroscience Research.

Citicoline wins EU novel foods approval – in medical foods and food supplements

Minor transient adverse effects are rare and most commonly include stomach pain and diarrhea. The brain preferentially uses choline to synthesize acetylcholine.

When the availability of choline is low or the ctiicoline for acetylcholine increases, phospholipids containing choline can be catabolized from neuronal membranes. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. In the US, Citicoline is a member of the drug class oral nutritional supplements. This limits the amount of choline available to synthesize phosphatidylcholine. Consult with your healthcare professional before taking any medication.


Phosphatidylcholine is a major phospholipid in eukaryotic cell membranes. Citicolime Read Edit View history.

Citicoline wins EU novel foods approval – in medical foods and food supplements

A meta-analysis of randomized controlled trials”. Citicoline is available as a supplement online and in stores.

Retrieved from ” https: Further information on drug naming conventions: The Journal of Biological Chemistry. By using this site, you agree to the Terms of Use and Privacy Policy. Subscribe to receive email notifications whenever new articles are published. This can lower levels of hydroxyl radicals produced after an ischemia and prevent cardiolipin from being catabolized by phospholipase A2.

Methods and Findings in Experimental and Clinical Pharmacology. Home International Citicoline Print Share. To view content sources and attributions, please refer to our editorial policy. A review of published clinical trials of citicoline noted that while some studies have demonstrated positive effects of the compound on cognition, other studies have failed to confirm these results and additional clinical trials would be needed to confirm any potential benefits of citicoline.

Nicotinic acetylcholine receptor modulators.

Citicoline INNalso known as cytidine diphosphate-choline CDP-Choline or cytidine 5′-diphosphocholine is an intermediate in fca generation of phosphatidylcholine from cholinea common biochemical process in cell membranes. Subscribe to free Drugs. Citicoline is naturally occurring in the cells of human and animal tissue, in particular the organs.


Further information Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. The neuroprotective effects exhibited by citicoline may be due to its preservation of cardiolipin and sphingomyelinpreservation of arachidonic acid content of phosphatidylcholine and phosphatidylethanolaminepartial restoration of phosphatidylcholine levels, and stimulation of glutathione synthesis and glutathione reductase activity.

This means it is still under development and may contain inaccuracies. We comply with the HONcode standard for trustworthy health information – verify here.

The effect of citicoline on visual function has been studied in patients with glaucoma. The Complete Drug Reference [ed. Citicoline also increases ctiicoline uptake by increasing expression of EAAT2a glutamate transporterin vitro in rat astrocytes. London UK ; e-version. This page was last edited on 14 Septemberat These phospholipids include sphingomyelin and phosphatidylcholine. Close regulation of its biosynthesis, degradation, and distribution is essential to proper cell function.

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