Cotula cinerea Del. belongs to the family Asteraceae. It is widely used in the traditional medicinal system for the treatment of various ailments such as colic. Cotula cinerea Delile [family COMPOSITAE ] (stored under name); Verified by Not on Brocchia kotschyi; Cotula kotschyi; Cotula cinerea; Brocchia cinerea. Abstract: The phytochemical investigation of Cotula cinerea Del. afforded eighteen Keywords: Cotula cinerea Del.; Asteraceae; Flavonoids; Germacranolide.

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The current widely used cancer treatments such as surgery, radiotherapy, systemic therapy, and chemotherapy are very expensive and cause several side and adverse effects [ 4 ]. After 24 h incubation, cells were then cotua with the essential oil of Cotula cinerea or its extracts hexane, ethyl acetate, and n -butanol in addition to those of Salvia verbenaca.

After 30 minutes of incubation at room temperature, absorbance was measured at nm using an ELISA plate reader. Before evaluating the antiproliferative activity, the cellular density of each species was determined using light microscopy.

Cotula – Wikipedia

From This Paper Figures, tables, and topics from this paper. The collected aerial parts were left under shade at room temperature until complete drying. From Wikipedia, the free encyclopedia.

These plants are widely used in the Moroccan traditional folk medicine. This genus was first mentioned by Carl Linnaeuswho described four species in his first edition of Species Plantarum.

Cell viability was evaluated by determination of the percentage of cytotoxicity using the formula given below. Cabrera Cotula microglossa DC. Furthermore, natural products could be as efficient as synthetic ones with no or less toxicity and are less expensive than synthetic drugs. However, and despite the widespread use of these plants in Moroccan traditional folk medicine, to the best of our knowledge, no information has been previously reported on the anticancer activity of Moroccan Cotula cinerea and Salvia verbenaca.


Exploring alternative sources of new antitumor agents with specific targets is thus imperative and of great and crucial importance.

This is an open access article distributed under the Creative Commons Attribution Licensewhich permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Gymnogyne Steetz Peyrousea DC. Mouzdahir A Huile essentielle de Santolina africana Jord.

Flavonoids from Cotula cinerea Del

This makes it difficult to define them by comparing their morphology. Articles with ‘species’ microformats Commons category link is on Wikidata Taxonbars with dinerea taxon IDs Taxonomy articles created by Polbot. Hilliard Cotula loganii Hutch. Cotula vulgaris Levyns Cotula zeyheri Fenzl.

The maceration process was repeated twice during 24 h each in order to achieve an exhaustive extraction. The obtained findings for the two cell lines RD and Vero are summarized in Figures 1 and 2respectively. The activity of an essential oil is generally attributed and influenced by the major compounds.

Moreover, a molecule could have an effect on one type of tumor and not on others. The absorbance of the formazan will then be determined by spectrophotometry at nm. In the case of the RD cell line, the Cotula cinerea hexane extract showed the higher cytotoxic effect followed by the ethyl acetate, the essential oil, and ciinerea n -butanol extract.


Indexed in Science Citation Index Expanded. Composition chimique et isolement vinerea deux principaux constituants. Lloyd has proposed that the five species from Australia and Cotuka Guinea are distinctive enough from the other species from the section Leptinella to be brought under a new section with the proposed name Oligoleima type species C.

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Cotula cotuloides Steetz Druce Cotula cryptocephala Sch. The exact mechanism through which the explored extracts act on each tumor cell line is obviously difficult to highlight. Correspondence should be addressed to Fatima-Ezzahrae Guaouguaou ; moc. Another characteristic is their solitary heads growing on a peduncle. Dinerea Cotula filifolia Thunb.

The sections possess different basic chromosome numbers:. These two species were obtained from the National Institute of Health, Rabat, Morocco, and were cultivated as previously described by Aneb et al. The genus can only be defined by looking at the corollas of their flowers. Essential oils are complex molecules containing various and several terpenoids compounds belonging mainly to monoterpene and sesquiterpene chemical groups and presenting different functional groups such as alcohols, phenols, ketone, etc.

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