Cotula cinerea Del. belongs to the family Asteraceae. It is widely used in the traditional medicinal system for the treatment of various ailments such as colic. Cotula cinerea Delile [family COMPOSITAE ] (stored under name); Verified by Not on Brocchia kotschyi; Cotula kotschyi; Cotula cinerea; Brocchia cinerea. Abstract: The phytochemical investigation of Cotula cinerea Del. afforded eighteen Keywords: Cotula cinerea Del.; Asteraceae; Flavonoids; Germacranolide.

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The tentative global mechanism gathered probably all these actions which are thus supposed to provide the observed cytotoxic effect. Then, solvents of the different obtained extracts were evaporated and the dried residues were used to explore their cytotoxic effect.

This study is expected thus to be beneficial for clinical and traditional applications for Cotula cinerea as a remedy against cancer and opens new perspectives for further exploration on other types of cancer cell lines. The exact mechanisms through which such compounds act in their cytotoxicity effect are not well known, but some tentative investigations suggested that these compounds could interrupt the life cycle cell, inducing the apoptosis pathways and inactivating the telomerase [ 6 ].

Results and Discussion In an ongoing program aimed at the exploration of the phytochemical compounds and the biological activities of medicinal plants of Morocco, we were interested, in this work, in the cytotoxic effect of Cotula cinerea and Salvia verbenaca.

BioMed Research International

This is an open access article cotulz under the Creative Commons Attribution Licensewhich permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The results are expressed as percentage of cytotoxicity versus the concentrations of the essential oil or extracts of both plants. El Btaouri et al. The two tumor tested cell lines used in this study were RD Human Embryonal Rhabdomyosarcoma cancerous cell lines: The maceration process was repeated twice during 24 h cinedea in order to achieve an exhaustive extraction.

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In the genus was subdivided by George Bentham [5] into three sections. It is thus important and imperative to find more effective drugs with a shorter application period. The main constituents of the essential oil are Camphor, Camphene, Alpha-pinene, 3-carene, Thujone, 4-terpineol, Z -betafarnesene and santolinatriene.

Lloyd cotulw proposed that the five species from Australia and New Guinea are distinctive enough from the other species from the section Leptinella to be brought under a new section with the proposed name Oligoleima type species C. From This Paper Figures, tables, and topics from this paper.

In the case of the Vero tumor cell line, Table 1 reveals that Cotula cinerea essential oil showed the highest cytotoxic capacity with the lowest Clnerea 50 value Another characteristic is their solitary heads growing on a peduncle.

Cotula – Wikipedia

In other projects Wikimedia Commons Wikispecies. This was observed for both cell lines. The sections possess different basic chromosome numbers:. For both lines, an increase of the cytotoxicity with the concentration of the essential oil or the used extracts was observed indicating a dose dependent effect. By using this site, you agree to the Terms of Use and Privacy Policy.

The extraction was achieved during six hours and the obtained oil yield 0. Since his account, only a few changes have been made but the number of species has remained more or less stable.

Despite the appreciable advancements and progress made in cancer treatment, it continues to constitute a serious global health problem, especially with the appearance of multidrug resistance cells. The antiproliferative activity of Cotula cinerea essential oil against the Vero tumor cell line could be due to presence of cytotoxic molecules in the oil.


Flavonoids from Cotula cinerea Del

Indeed, the antitumor properties of phenolic compounds and flavonoids against several cell lines representing numerous human cell lines have been previously reported [ 6 ]. The obtained values are correlated with the metabolized intracellular MTT concentrations and are therefore proportional to the number of living cells.


References Publications referenced by this paper.

Traditional forms of medicine, especially cunerea herbal products deployed for centuries in many parts of the world, could be good alternative for scientific investigation due to their attributes against tumor cell lines. Cotula macroglossa Bolus ex Schltr.

In the case of the RD cell line, the Cotula cinerea hexane extract showed the higher cytotoxic effect followed by the ethyl acetate, the essential oil, and the cinerfa -butanol extract. An examination of the obtained results showed cienrea the cytotoxic effects of the investigated plants extracts were different according to the tested cell line with an efficient activity dinerea Cotula cinerea compared to Salvia verbenaca.

Evaluation of the Cytotoxicity Before evaluating the antiproliferative activity, the cellular density of each species was determined using light microscopy. Those of Salvia verbenaca were collected on March at the locality called Ain Aouda, in the Rabat region, Morocco. Levyns Cotula elongata B. Moreover, a molecule could have an effect on one type of tumor and not on others.

Cotula cotuloides Steetz Druce Cotula cryptocephala Sch. Cotula socialis Hilliard Cotula sororia DC. Oils, Volatile Search for additional papers on this topic. The essential oil and the ethyl acetate extract showed moderate cytotoxic effects The absorbance of the formazan will then be determined by spectrophotometry at nm.

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