Description. Cremophor A 6 is a whitish waxy substance. Cremophor A 25 is supplied in the form of free-flowing, non-dusting microbeads. Identity. Cremophor A. August Supersedes issue dated May MEMC e/Page 1 of 8. Cremophor® A Grades. ® = Registered trademark of BASF Aktiengesellschaft. INCI: Ceteareth-6 (and) Stearyl AlcoholThe Cremophor A grades are Combinations of Cremophor A6 and Cremophor A25 can emulsify oils with a.
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Investigation of emulsions with novel surfactants is another potential direction for formulation improvement, but this approach is less favored because of the added burden z6 having to prove the harmlessness of each new emulsifier. Crit Rev Toxicol ; Improved brain delivery and in vitro activity of zidovudine through the use of a redox chemical delivery system. The stability of fat emulsions for intravenous administration, Advances in Clinical Nutrition.
Post was not sent – check your email addresses! Likewise, in its cationic form, it may also neutralize the negative surface charges. The fatty acids contained in soybean oil triglycerides administered to the body are predominantly linoleic Metabolic acidosis and fatal myocardial failure creomphor propofol infusion in children: However, freeze—thawing and extensive shaking caused droplet enlargement.
Use of cdemophor and other nonbenzodiazepine crmophor in the intensive care unit. However, only propofol emulsions containing disodium edetate disodium ethylenediaminetetraacetate [EDTA] or sodium metabisulfite are currently approved by the Food and Drug Administration for marketing in the United States.
It is a simple phenol substituted with two isopropyl groups in each of the positions adjacent to the hydroxyl group, the ortho positions fig. Propofol phosphate, a water-soluble propofol prodrug: The clinical and biochemical effects of propofol infusion with and without EDTA for maintenance anesthesia in healthy children undergoing ambulatory surgery.
Pancreatitis is common among patients with primary or secondary hypertriglyceridemia. Major factors that govern this process for propofol or any cremohpor drug are the drug concentration gradient, the partition coefficient, the drug diffusivity in both phases, and the interfacial area of the drug-containing oil droplets.
In general, emulsions with droplets of 0. After droplets coalesce and increase in size, they cannot be reduced in size except by rehomogenization. Selection of disodium edetate as the optimal antimicrobial additive for use in propofol emulsion.
In view of these results, more study is needed to determine the effects of droplet enlargement and lipid aggregation on tissue perfusion from such infusions. The effect of a change of formulation on the incidence of pain after intravenous injection.
Consequently, extensive droplet enlargement in emulsions can occur and not be detected by visual inspection. A drawback of propofol prodrugs is that free propofol is dependent on the rate of molecular degradation of the prodrug in vivo. Anesthesiology 10Vol. To add an email address to your ASA account please contact us:.
These molecules bridge the interface between the dispersed oil droplets and water. Hypertriglyceridaemia associated with propofol administration.
CREMOPHOR (R) A6 |
Medium-chain fatty acids MCTs are those with hydrocarbon chains from 6 to 10 carbons long and are in high concentrations in coconut oil and palm kernel oil, for example. The viscosity of these solutions are said to be similar to that of the current propofol oil-in-water emulsions.
Eur J Pharm Sci ; And we are helping to provide a reliable supply of high quality food, feed and plant based raw materials.
Propofol prodrugs are compounds that will degrade, usually in the bloodstream, to release the propofol molecule. Paediatr Anaesth ; The preparation and properties of sterile intravenous emulsions. Pharmaceutical suspensions, Pharmaceutical Dosage Forms: Food Chem Toxicol ; I need to go to bed.