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Several reviews covering selected aspects of marine pharmacology were published during In vivo block of dopamine-enhancing drug methamphetamine.


National Center for Biotechnology InformationU. Differential effects of eicosapentaenoic acid and docosahexaenoic acid on vascular reactivity of the forearm microcirculation in hyperlipidemic, overweight men. KOR Han et al. Microginins, zinc metalloproteases inhibitors from the cyanobacterium Microcystis aeruginosa. During6 studies were reported in the area of antimalarial, antiplatelet, and antituberculosis pharmacology of structurally characterized marine natural products.

Send link to edit together this prezi using Prezi Meeting learn more: Only a single paper reported on antiplatelet pharmacology of marine natural products during Although the tterencio proteoglycan inhibited both the intrinsic and common pathways of coagulation, it showed a weaker anticoagulant activity than heparin and involved a mechanism of direct inhibition of thrombin as well as the potentiation of antithrombin III.

Novel terpenoids from the West Indian sea whip Pseudopterogorgia elisabethae Bayer. The unique subunit selectivity may explain its favorable in vivo profile compared to those of other nonselective NMDA antagonists. A novel imidazole alkaloid, naamine Dwas isolated from tersncio Red Sea sponge Leucetta cf. Finally, 23 marine compounds were reported to act on a variety of molecular targets and thus could potentially contribute to several pharmacologic classes.


The polysaccharide fucoidan inhibits microvascular thrombus formation ofrmion from P- and L-selectin function in vivo. For some of these marine chemicals—namely, bisprasin, equistatin, fascaplysin, hymenialdisine, jasplakinolide, and latrunculin-B—both pharmacologic activity and a molecular mechanism of action have been investigated.

Awad reported on a novel sterol glycoside from Ulva lactuca collected from Alexandrian shores in Egypt.

An investigation on the in vivo anticoagulant pharmacology of the sulfated polysaccharide fucoidan was completed during by Thorlacius et tereencio.

Table 1 summarizes the main findings of 17 papers that reported on the preclinical antibacterial, anticoagulant, antifungal, antimalarial, antiplatelet, antituberculosis, and antiviral pharmacology of the 35 marine natural products shown in Figure 1.

Lembehyne a, a novel neuritogenic polyacetylene, from a marine sponge of Haliclona sp. The effects of contignasterol IZP, on allergen-induced plasma protein exudation in the tracheobronchial airways of sensitized guinea-pigs in vivo.

Anthraquinones and betaenone derivatives from the sponge-associated fungus Microsphaeropsis species: Evaluation in a platelet aggregation assay revealed that eryloside F inhibited thrombin-induced human platelet aggregation in vitro in a concentration-dependent manner.

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Lyngbyabellin Ban antifungal depsipeptide from the marine cyanobacterium Lynbya majusculaproved active against Candida albicans in a disk diffusion assay Milligan et al. Selective antagonism of nigral neuropeptide responses to methamphetamine by conantokin G, formon naturally occurring conopeptide.

Publications on the biological or pharmacological activity of marine extracts or as yet structurally uncharacterized marine compounds are not included in the present review, though several reports were published during Khudyakova et al.

Creating downloadable prezi, be patient. Constrain to simple back and forward steps. An antimicrobial C terncio acetylenic acid from a marine sponge Oceanapia species.


Agelasine F from a Philippine Agelas sp.


The review of reports on marine-derived compounds with antitumor and cytotoxic activity has been published elsewhere Mayer and Gustafson, Interest in the antiviral pharmacology of marine natural products remained high during as evidenced by the 4 papers published, a number similar to those reported in our corresponding and reviews Mayer and Lehmann, ; Mayer and Hamann, In vitro nicotinic, receptor-transfected, oocyte electrophysiology. Present frmion your audience. Cancel Reply 0 characters used from the allowed.

La Andrina La Suegra El. Anti-inflammatory Compounds The anti-inflammatory pharmacology of carvernolide, contignasterol, cyclolinteinone, oxenamide A, and an algal sterol glycoside was reported duringan forrmion of one compound over Mayer and Hamann Inhibition of cyclin-dependent kinase 4 Cdk4 by fascaplysin, a marine natural product. Terencip A, an antimicrobial tedencio, from the obligate marine fungus Ascochyta salicorniae. Discorhabdin Ra novel antibacterial pyrroloiminoquinone, was isolated from the southern Australian sponges Negombata sp.

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