Hydranencephaly after Maternal Butane-gas Intoxication during Pregnancy . Hydranence’phalie apr.?s intoxication maternelle par le gaz butane durant la. Autoerotic Accident by Inhalation of Propane-Butane Gas Mixture Toxicologic investigations revealed an intoxication with propane and butane .. kan ve doku örneklerinde gaz komponentlerinin analizinin yap›labilmesi tan›. Butane is a colourless and flammable gas with a gasoline-like or natural gas This paper discusses the medico-legal approach for this type of intoxication.
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The animals were observed for h after exposure. A case report and literature review. Cranial computed tomography revealed two fluid-filled cavities separated by a intoxucation midline falx cerebri Fig. Dependence is usually psychological rather than physical. A total uncertainty factor of 3 is considered sufficient to account for toxicokinetic and toxicodynamic differences between individuals and interspecies differences for the following reasons.
Although a table in the report indicated that exposure to butane at 10, ppm for 10 buane caused drowsiness, this was contradicted by a statement in the text intxoication min exposure to butane 10, ppm caused no symptoms. Dogs Six dogs were exposed to butane for various durations to study its potency as a cardiac sensitizer Chenoweth Estos hallazgos eran compatibles con hidranencefalia.
Also, no noticeable irritation was reported at concentrations up toppm probably for a few minand a larger uncertainty factor of 3 would lead to unrealistically low AEGL-1 values. Department of Public Health Sciences.
Inhalation of butane can cause euphoriadrowsinessunconsciousnessasphyxiacardiac arrhythmiafluctuations in blood pressure and temporary memory loss, when abused directly from a highly pressurized container, and can result in death from asphyxiation and ventricular fibrillation. A year-old boy was found unconsciousness as a result of butane abuse; he died 34 h after the exposure despite resuscitation efforts Rieder-Scharinger et al.
Nuckolls exposed groups of three guinea pigs to butane at 21, intoxicatio or 50, ppm for 5, 30, 60, or min. No irritation was noted atppm exposure duration not specified but was probably for a few minutes.
No irritation was reported atppm for 10 min.
For 5 days she remained cardiovascularly stable with persistent T-wave inversion on the electrocardiogram. Of the 15 trials with individual dogs, three resulted in ventricular fibrillation. Therefore, the starting point for the min and the 1- 4- and 8-h values were the 2-h steady-state value of 50, ppm.
In an intermittent exposure test, subjects were exposed at fixed concentration for a short, unspecified duration. Sign up to our eBulletin. The experimental procedure in the study by Stoughton and Lamson is poorly described, but suggests that the reported concentrations of butane are probably initial concentrations in a closedchamber setting.
The initial cardiac rhythm was ventricular asystole. Les ktudes Cchographiques et neuroradiologiques scanner et angiographie ont montrk une absence pratiquement complbte des deux hCmisphbres ckr6braux.
Odor thresholds and irritation levels of several chemical substances: The database for butane is poor and important studies date back to the s or s. Derivation of AEGL-2 Case reports indicate that single exposure to high concentrations of butane might cause severe brain damage in the fetus, but no adequate human or animal data are available for a quantitative evaluation of this end point.
La madre inha16 accidentalmente gas butano a 10s seis meses de gestaci6n. No deaths occurred in mice exposed for 2 h atorppm. No AEGL-1 effects at 10, ppm for 10 min. He was resuscitated during which he received epinephrine. Quantitative data for setting AEGL values are sparse.
Hence, the rationale described in Section 6. These data are only briefly described because they provide no clear dose-response data ai, for abuse cases, subjects generally have a history of repeated exposure, so tolerance to butane could have developed Evans and Raistrick Concentration-time mortality response relationship of irritant and systemically acting vapours and gases; pp.
Butane | C4H10 – PubChem
Complete anesthesia from butane was reported to occur at an initial concentration ofppm after 15 min,ppm after 4 min, andppm after 3 min. Therefore, the AEGL-3 values for 30 min and for 1, 4 and 8 h of exposure will be set equal to that for the 2-h exposure.
Skip to main content. The study by Stoughton and Lamson provides a no-observedadverse-effect level for lethality in mice exposed to butane for 2 h. Normal butane can be used for gasoline blending, ijtoxication a fuel gas, fragrance extraction solvent, either alone or in a mixture with propaneand as a feedstock for the manufacture of ethylene and butadienea key ingredient of synthetic rubber. A pregnant year-old woman accidentally inhaled butane in during week 27 of her pregnancy.
Death during deliberate propane inhalation. Most of these cases involved inhalant abusers with repetitive exposure to butane. Exposure concentrations were reported to be controlled by gas chromatography, but no information aj the concentrations of butane tested or the duration of the post-exposure observation period was provided.
Hemispheric vessels are either absent or extremely attenuated; vessels irrigating midline basal remnants of parenchyma are preserved arrow. LC 16 ratio was 1. No data other than that described in Sections 3. The concentration-response curve was very steep, with LC Le thalamus, le tronc c6rkbral butanee le cervelet Ctaient indemnes.
Clear central nervous system CNS effects were reported by butane abusers, including disturbed behavior, slow speech, elated mood, hallucinations, and illusionary experiences. This is consistent with other anesthetics for which effects are assumed to be concentration dependent rather than time dependent.
Suicide by Inhalation of Suffocative Gas
For similar reasons and because subjects exposed at slowly increasing concentrations of intoxicatlon up to 50, ppm for at least 10 min did not experience any significant adverse effects, a modifying factor is not considered necessary.
View in own window. However, the mice were probably exposed in a closed-chamber setting and the reported butane concentrations might refer to initial concentrations.